Developing strategies for HIV-1 eradication
نویسندگان
چکیده
منابع مشابه
Novel immunological strategies for HIV-1 eradication
Despite the significant advances in antiretroviral therapy (ART), HIV-1 is able to persist in cellular reservoirs. Preclinical studies suggest that the latent reservoir is established within days of virus exposure, even before virus can be detected in peripheral blood. Latently infected cells remain undetectable by the immune system and can persist for years without losing their ability to prod...
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Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4(+) T cells and perhaps other long-lived cellular reservoirs. In this...
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HIV induces persistent infection and, despite improvements in mortality and morbidity conferred by Highly Active Antiretroviral Therapy (HAART), there is currently no cure [1]. The immune system controls HIV only partially, and plasma HIV and proviral DNA can be detected from acute primary infection to end-stage AIDS [2]. More than 99% of HIV replication has been demonstrated in activated and i...
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The quantitative viral outgrowth assay (QVOA) provides a precise minimal estimate of the reservoir of resting CD4(+) T-cell infection (resting cell infection [RCI]). However, the variability of RCI over time during antiretroviral therapy (ART), relevant to assess potential effects of latency-reversing agents or other interventions, has not been fully described. We performed QVOA on resting CD4(...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2012
ISSN: 1471-4906
DOI: 10.1016/j.it.2012.07.001